Abstract
A bone morphogenetic protein bioimplant was used for primary reconstruction of a 6-cm mandibular discontinuity defect, after a segmental resection of an ameloblastoma. Radiographic evidence of new bone induction was seen at 3 and 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation at the bioimplant site. This is the first reported case using a bone morphogenetic protein bioimplant in a human, followed by histological confirmation of new bone.
MeSH terms
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Adult
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Ameloblastoma / surgery*
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Biopsy
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Bone Matrix / transplantation*
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Bone Morphogenetic Proteins / therapeutic use*
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Bone Plates
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Bone Screws
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Bone Substitutes / therapeutic use*
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Drug Carriers
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Follow-Up Studies
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Gels
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Humans
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Male
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Mandible / diagnostic imaging
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Mandible / pathology
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Mandible / surgery*
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Mandibular Neoplasms / surgery*
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Osteocytes / pathology
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Osteogenesis / drug effects
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Osteogenesis / physiology
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Osteotomy
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Poloxamer
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Radiography
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Transplantation, Homologous
Substances
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Bone Morphogenetic Proteins
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Bone Substitutes
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Drug Carriers
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Gels
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Poloxamer