Successful mandibular reconstruction using a BMP bioimplant

J Craniofac Surg. 2001 Mar;12(2):119-27; discussion 128. doi: 10.1097/00001665-200103000-00005.

Abstract

A bone morphogenetic protein bioimplant was used for primary reconstruction of a 6-cm mandibular discontinuity defect, after a segmental resection of an ameloblastoma. Radiographic evidence of new bone induction was seen at 3 and 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation at the bioimplant site. This is the first reported case using a bone morphogenetic protein bioimplant in a human, followed by histological confirmation of new bone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ameloblastoma / surgery*
  • Biopsy
  • Bone Matrix / transplantation*
  • Bone Morphogenetic Proteins / therapeutic use*
  • Bone Plates
  • Bone Screws
  • Bone Substitutes / therapeutic use*
  • Drug Carriers
  • Follow-Up Studies
  • Gels
  • Humans
  • Male
  • Mandible / diagnostic imaging
  • Mandible / pathology
  • Mandible / surgery*
  • Mandibular Neoplasms / surgery*
  • Osteocytes / pathology
  • Osteogenesis / drug effects
  • Osteogenesis / physiology
  • Osteotomy
  • Poloxamer
  • Radiography
  • Transplantation, Homologous

Substances

  • Bone Morphogenetic Proteins
  • Bone Substitutes
  • Drug Carriers
  • Gels
  • Poloxamer